Search by BoMiProt ID - Bomi7232


Primary Information

BoMiProt ID Bomi7232
Protein Name mRNA-decapping enzyme 1B
Organism Bos taurus
Uniprot IDQ3SZL6
Milk FractionWhey
Ref Sequence ID NP_001029639.1
Aminoacid Length 581
Molecular Weight 62880
FASTA Sequence Download
Gene Name DCP1B
Gene ID 514548
Protein Existence Status reviewed

Secondary Information

Protein Function Decapping enzymes.Participate in degradation of mRNAs both in normal mRNA turnover and in nonsense-mediated mRNA decay.
Biochemical Properties Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP.
PTMs Phosphorylation on Ser and Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q3SZL6|DCP1B_BOVIN mRNA-decapping enzyme 1B OS=Bos taurus OX=9913 GN=DCP1B PE=2 SV=1 MAVAGGPAGKGRDISLAALRRHDPYISRIVDVASQVALYTFGHRANEWEKTDVEGTLFVY SRSASPKHGFTIMNRLSMENRTEPITKDLDFLLQDPFLLYRNARLSIYGIWFYDKEECQR IAELMKNLTQYEQLKAHHGTGAGAS*145PVSLGSGEGKEADILRMLTKAKDEYTKCKTCSEPK QISSSSAIHDNPNLIKPIPVKPSGSRQQRGPRPGQTSDPEPQHLSLTALFGKQDKAPCQE ATGPPQTLPLQQQQPEKFPMRQGVVRSLS*269YEEPRRPSPPVDKQLCPAIQKLMVRSMDLQP LAELPESRPCTDALRAACAGPAQT*324GSPRSHALAAPGTQKLLQVQSIPGAENRCEPGAPAP ASSATT*366PVSLAQPTRLSSALPPQTPGPRALPRPAPPGPGPGHQPVTGPGEVS*412PRELLRRL QAVQQEQQLPAPGRPALAAKFPTATLSTRARNPLEPWRDPPPSTEQPAPLLQVLS*475PQRIP AAATPPPLMSPLVFAQPSWAPPQERSRAPLPPGNQDPAATPTGLLLPLRTPEPPGTPGSA LSKLQLQEALLHLIQNDDNFLNIIYEAYLFSLTQAAVKKTL
Predicted Disorder Regions 141-152, 171-185, 196-219, 244-270, 307-315, 319-346, 362-382, 406-418, 440-461, 482-533
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Lykke-Andersen J. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol Cell Biol. 2002 Dec;22(23):8114-21. doi: 10.1128/MCB.22.23.8114-8121.2002. PMID: 12417715; PMCID: PMC134073.