Primary Information | |
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BoMiProt ID | Bomi723 |
Protein Name | DnaJ homolog subfamily C member 12 |
Organism | Bos taurus |
Uniprot ID | Q9N287 |
Milk Fraction | Exosome |
Ref Sequence ID | NP_776521.1 |
Aminoacid Length | 198 |
Molecular Weight | 23269 |
FASTA Sequence | Download |
Gene Name | DNAJC12 |
Gene ID | 281259 |
Protein Existence Status | Reviewed: Experimental evidence at transcript level |
Secondary Information | |
Protein Function | DnaJ proteins, also known as heat shock protein 40 (Hsp40 or Hsc40) act as cochaperones to the molecular chaperone DnaK (Hsp70), which is responsible for several cellular processes such as rescuing misfolded proteins, folding polypeptide chains, transport of polypeptides through membranes, assembly and disassembly of protein complexes, and control of regulatory proteins; primarily facilitates the hydrolysis of ATP from DnaK that is necessary for the chaperone activity of DnaK; DNAJA1 appears to be involved in importing proteins into the mitochondria |
Significance in milk | heat stress proteins in mamary gland |
Linking IDs | Bomi56 |
Bibliography | 1. Li, L., Sun, Y., Wu, J., Li, X., Luo, M., & Wang, G. (2015). The global effect of heat on gene expression in cultured bovine mammary epithelial cells. Cell Stress & Chaperones, 20(2), 381–389. https://doi.org/10.1007/s12192-014-0559-7. 2. Stark, J. L., Mehla, K., Chaika, N., Acton, T. B., Xiao, R., Singh, P. K., … Powers, R. (2014). Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry, 53(8), 1360–1372. https://doi.org/10.1021/bi401329a. |
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation | |
Predicted Disorder Regions | 112-167 |
DisProt Annotation | |
TM Helix Prediction | No TM helices |