Search by BoMiProt ID - Bomi723


Primary Information

BoMiProt ID Bomi723
Protein Name DnaJ homolog subfamily C member 12
Organism Bos taurus
Uniprot IDQ9N287
Milk FractionExosome
Ref Sequence ID NP_776521.1
Aminoacid Length 198
Molecular Weight 23269
FASTA Sequence Download
Gene Name DNAJC12
Gene ID 281259
Protein Existence Status Reviewed: Experimental evidence at transcript level

Secondary Information

Protein Function DnaJ proteins, also known as heat shock protein 40 (Hsp40 or Hsc40) act as cochaperones to the molecular chaperone DnaK (Hsp70), which is responsible for several cellular processes such as rescuing misfolded proteins, folding polypeptide chains, transport of polypeptides through membranes, assembly and disassembly of protein complexes, and control of regulatory proteins; primarily facilitates the hydrolysis of ATP from DnaK that is necessary for the chaperone activity of DnaK; DNAJA1 appears to be involved in importing proteins into the mitochondria
Significance in milk heat stress proteins in mamary gland
Linking IDs Bomi56
Bibliography 1. Li, L., Sun, Y., Wu, J., Li, X., Luo, M., & Wang, G. (2015). The global effect of heat on gene expression in cultured bovine mammary epithelial cells. Cell Stress & Chaperones, 20(2), 381–389. https://doi.org/10.1007/s12192-014-0559-7.
2. Stark, J. L., Mehla, K., Chaika, N., Acton, T. B., Xiao, R., Singh, P. K., … Powers, R. (2014). Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry, 53(8), 1360–1372. https://doi.org/10.1021/bi401329a.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 112-167
DisProt Annotation
TM Helix Prediction No TM helices