Search by BoMiProt ID - Bomi7206


Primary Information

BoMiProt ID Bomi7206
Protein Name Monocarboxylate transporter 13
Organism Bos taurus
Uniprot IdQ17QR6
Milk FractionWhey
Ref Sequence Id NP_001069600.1
Aminoacid Length 426
Molecular Weight 44713
Fasta Sequence https://www.uniprot.org/uniprot/Q17QR6.fasta
Gene Name SLC16A13
Gene Id 538855
Protein Existence Status reviewed

Secondary Information

Protein Function Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.pivotal role in brain energy metabolism.MCT may play a role in the intestinal absorption of nateglinide. MCT may play a role in bumetanide’s brain penetration.
Biochemical Properties transport a small set of xenobiotics: bumetanide, nateglinide, probenecid, and prostaglandin F2α; a series of aglycone flavonoids have been identified as inhibitors.
Significance in milk involvement in the transport of short-chain monocarboxylates, aromatic amino acids, and thyroid hormones across the mammary alveolar epithelial cells to be utilized for milk synthesis and secretion in lactating cattle.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1 disordered segment; (405-426)
DisProt Annotation
TM Helix Prediction 11TMHs; (13-31), (82-100), (107-129), (141-163), (170-192), (219-241), (248-266), (278-300),(307-329), (341-363), & (370-392)
Bibliography 1.Kirat D, Kato S. Monocarboxylate transporter genes in the mammary gland of lactating cows. Histochem Cell Biol. 2009 Oct;132(4):447-55. doi: 10.1007/s00418-009-0621-1. Epub 2009 Jul 28. PMID: 19636583. 2.Felmlee MA, Jones RS, Rodriguez-Cruz V, Follman KE, Morris ME. Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease. Pharmacol Rev. 2020 Apr;72(2):466-485. doi: 10.1124/pr.119.018762. PMID: 32144120; PMCID: PMC7062045.