Search by BoMiProt ID - Bomi7163


Primary Information

BoMiProt ID Bomi7163
Protein Name Mitogen-activated protein kinase 1/ERT1/Extracellular signal-regulated kinase 2/Mitogen-activated protein kinase 2
Organism Bos taurus
Uniprot IDP46196
Milk FractionExosomes
Ref Sequence ID NP_786987.1
Aminoacid Length 360
Molecular Weight 41376
FASTA Sequence Download
Gene Name MAPK1
Gene ID 327672
Protein Existence Status Reviewed

Secondary Information

Protein Function  MAPK1 is a member of the extracellular-signal regulated kinases (ERKs), playing roles in cell proliferation, differentiation, and development.This is mainly in response to growth factors, mitogens, and many environmental stresses.
Biochemical Properties MAPK1 (also known as ERK2) is the second member in the ERK subfamily, which contains a highly conserved serine/threonine kinase domain.AbMAPK1 possesses two N-glycosylation sites, one S_TK catalytic domain, and a conserved His-Arg-Asp domain (HRD). In addition, a conservative glycine rich ATP-phosphate-binding loop and a threonine-x-tyrosine motif (TEY) important for the autophosphorylation is also found.
PTMs N-Acetylation at Ala, Phosphorylation at Ser/Thr,Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P46196|MK01_BOVIN Mitogen-activated protein kinase 1 OS=Bos taurus OX=9913 GN=MAPK1 PE=2 SV=3 MAAAAAAGAGPEMVRGQVFDVGPRYTNLS*29YIGEGAYGMVCSAYDNVNKVRVAIKKISPFE HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH TGFLT*185EY*187VAT*190RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI LGILGS*246PS*248QEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADS*284KALDLLDKMLTFNPHK RIEVEQALAHPYLEQYYDPSDEPVAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
Predicted Disorder Regions 1-12,
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2.
Bibliography 1.Perera NCN, Godahewa GI, Lee J. Mitogen-activated protein kinase 1 from disk abalone (Haliotis discus discus): Roles in early development and immunity-related transcriptional responses. Fish Shellfish Immunol. 2016 Dec;59:57-65. doi: 10.1016/j.fsi.2016.10.031. Epub 2016 Oct 17. PMID: 27765698.