Search by BoMiProt ID - Bomi7156


Primary Information

BoMiProt ID Bomi7156
Protein Name Mitochondrial uncoupling protein 3/Solute carrier family 25 member 9
Organism Bos taurus
Uniprot IdO77792
Milk FractionWhey
Ref Sequence Id NP_776635.1
Aminoacid Length 311
Molecular Weight 34206
Fasta Sequence https://www.uniprot.org/uniprot/O77792.fasta
Gene Name UCP3/SLC25A9
Gene Id 281563
Protein Existence Status reviewed

Secondary Information

Protein Function expressed in skeletal muscle,mitochondrial transporter/proton channel that participate in thermiogenesis.UCP3 expression may be stimulated when a large amount of glucose or FFA influx occcurs in skeletal muscles to prevent excessive production of ATP and ADP homeostasis.plays a role in peripheral CD4+ T cell activation and differentiation towards different effector Th subsets.
Biochemical Properties six membrane-spanning α-helix,that are connected by three long matrix loops and two shorter intermembrane (IMS) space loops.N- and C-termini are located in the IMS.The protein displays a tripartite structure.
Significance in milk fatty acid metabolism
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-12, 50-54
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Tsuboyama-Kasaoka N, Ezaki O. Mitochondrial uncoupling protein 3 (UCP3) in skeletal muscle. Front Biosci. 2001 Mar 1;6:D570-4. doi: 10.2741/kasaoka. PMID: 11229874. 2.Pohl EE, Rupprecht A, Macher G, Hilse KE. Important Trends in UCP3 Investigation. Front Physiol. 2019 Apr 30;10:470. doi: 10.3389/fphys.2019.00470. PMID: 31133866; PMCID: PMC6524716.