Primary Information |
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BoMiProt ID | Bomi7155 |
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Protein Name | Mitochondrial uncoupling protein 2 |
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Organism | Bos taurus |
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Uniprot ID | Q3SZI5 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001028783.1 |
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Aminoacid Length | 309 |
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Molecular Weight | 33274 |
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FASTA Sequence |
Download |
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Gene Name | UCP2 |
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Gene ID | 281562 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | mitochondrial transporter protein.uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy(ATP) is dissipated in the form of heat.UCP2 in protecting cancer cells from an excessive production of mitochondrial superoxide ions .The UCP system represents an acute and energetically costly mechanism to decrease ROS production in mitochondria.it is estimated that 0.2%-2% of the O2 consumed in mitochondria is reduced to superoxide by electron leakage. |
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Biochemical Properties | Acts as a dimer forming a proton channel. |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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Predicted Disorder Regions | NA |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | Donadelli M, Dando I, Dalla Pozza E, Palmieri M. Mitochondrial uncoupling protein 2 and pancreatic cancer: a new potential target therapy. World J Gastroenterol. 2015 Mar 21;21(11):3232-8. doi: 10.3748/wjg.v21.i11.3232. PMID: 25805929; PMCID: PMC4363752. |