Search by BoMiProt ID - Bomi7155


Primary Information

BoMiProt ID Bomi7155
Protein Name Mitochondrial uncoupling protein 2
Organism Bos taurus
Uniprot IdQ3SZI5
Milk FractionWhey
Ref Sequence Id NP_001028783.1
Aminoacid Length 309
Molecular Weight 33274
Fasta Sequence https://www.uniprot.org/uniprot/Q3SZI5.fasta
Gene Name UCP2
Gene Id 281562
Protein Existence Status reviewed

Secondary Information

Protein Function mitochondrial transporter protein.uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy(ATP) is dissipated in the form of heat.UCP2 in protecting cancer cells from an excessive production of mitochondrial superoxide ions .The UCP system represents an acute and energetically costly mechanism to decrease ROS production in mitochondria.it is estimated that 0.2%-2% of the O2 consumed in mitochondria is reduced to superoxide by electron leakage.
Biochemical Properties Acts as a dimer forming a proton channel.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Donadelli M, Dando I, Dalla Pozza E, Palmieri M. Mitochondrial uncoupling protein 2 and pancreatic cancer: a new potential target therapy. World J Gastroenterol. 2015 Mar 21;21(11):3232-8. doi: 10.3748/wjg.v21.i11.3232. PMID: 25805929; PMCID: PMC4363752.