Search by BoMiProt ID - Bomi7152


Primary Information

BoMiProt ID Bomi7152
Protein Name Mitochondrial trifunctional protein, beta subunit/TP-beta/Acetyl-CoA acyltransferase/Beta-ketothiolase/3-ketoacyl-CoA thiolase
Organism Bos taurus
Uniprot IdO46629
Milk FractionWhey
Ref Sequence Id NP_776761.1
Aminoacid Length 475
Molecular Weight 51345
Fasta Sequence https://www.uniprot.org/uniprot/O46629.fasta
Gene Name HADHB
Gene Id 281811
Protein Existence Status reviewed

Secondary Information

Protein Function This enzyme catalyzes the last three reactions of the mitochondrial beta-oxidation pathway.HADHB reduces cancer cell migration and invasiveness, probably acting as a tumor suppressor gene.
Biochemical Properties The β subunit, encoded by the HADHB gene that is found on chromosome 2p23.3, catalyzes the thiolase activity.
Significance in milk fatty acid oxidation
PTMs Acetylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction no TM helices
Bibliography Miyajima, H., Ouchi, Y., Sakamoto, M., Takahashi, Y., Kono, S., & Suzuki, H. (2001). Increased anaerobic glycolysis in mitochondrial trifunctional protein-deficient brain. Journal of the neurological sciences, 184(2), 197–201. https://doi.org/10.1016/s0022-510x(01)00445-2