Search by BoMiProt ID - Bomi7149


Primary Information

BoMiProt ID Bomi7149
Protein Name Mitochondrial ribosome-associated GTPase 1
Organism Bos taurus
Uniprot IdQ4PS77
Milk FractionWhey
Aminoacid Length 332
Molecular Weight 37004
Fasta Sequence https://www.uniprot.org/uniprot/Q4PS77.fasta
Gene Name MTG1
Gene Id 509768
Protein Existence Status reviewed

Secondary Information

Protein Function a conserved ribosome assembly guanosine triphosphatase MTG1 controls mitochondrial translation by coupling mt Large subunit assembly with intersubunit bridge formation using the intrinsic GEF activity acquired by the mtSSU through mS27(GEF), a unique occurrence in translational systems.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-7, 273-279, 326-332
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments  MTG1-silencing in human cardiomyocytes and developing zebrafish revealed early cardiovascular lesions.
Bibliography Kim HJ, Barrientos A. MTG1 couples mitoribosome large subunit assembly with intersubunit bridge formation. Nucleic Acids Res. 2018 Sep 19;46(16):8435-8453. doi: 10.1093/nar/gky672. PMID: 30085276; PMCID: PMC6144824.