Search by BoMiProt ID - Bomi7133


Primary Information

BoMiProt ID Bomi7133
Protein Name Mitochondrial 2-oxodicarboxylate carrier
Organism Bos taurus
Uniprot IdA0JN87
Milk FractionWhey
Ref Sequence Id XP_005222099.1
Aminoacid Length 299
Molecular Weight 33108
Fasta Sequence https://www.uniprot.org/uniprot/A0JN87.fasta
Gene Name SLC25A21
Gene Id 513423
Protein Existence Status reviewed

Secondary Information

Protein Function SLC25A21 transports 2-oxoadipate and 2-oxoglutarate across the inner membrane of mitochondria by a counterexchange mechanism
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1 disordered segment; (1-12)
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy–like disease
Bibliography Boczonadi V, King MS, Smith AC, Olahova M, Bansagi B, Roos A, Eyassu F, Borchers C, Ramesh V, Lochmüller H, Polvikoski T, Whittaker RG, Pyle A, Griffin H, Taylor RW, Chinnery PF, Robinson AJ, Kunji ERS, Horvath R. Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy-like disease. Genet Med. 2018 Oct;20(10):1224-1235. doi: 10.1038/gim.2017.251. Epub 2018 Mar 8. Erratum in: Genet Med. 2019 Sep;21(9):2163-2164. PMID: 29517768; PMCID: PMC6004311.