Search by BoMiProt ID - Bomi7112


Primary Information

BoMiProt ID Bomi7112
Protein Name Microsomal glutathione S-transferase 2/Glutathione peroxidase MGST2 /Leukotriene C4 synthase MGST2
Organism Bos taurus
Uniprot IdQ2KJG4
Milk FractionWhey
Ref Sequence Id NP_001069850.1
Aminoacid Length 146
Molecular Weight 16483
Fasta Sequence https://www.uniprot.org/uniprot/Q2KJG4.fasta
Gene Name MGST2
Gene Id 615552
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells  cortex of kidney 
Protein Function Human microsomal glutathione transferase 2 (MGST2) is a trimeric integral membrane protein that belongs to the membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) family. 
Biochemical Properties The mammalian MAPEG members are integral membrane proteins localized to the endoplasmic reticulum and perinuclear membrane. They are 10–45% sequence identical and can be divided into three types based on primary structures. MGST1 and microsomal prostaglandin (PG) E synthase-1 (mPGES-1) constitute one type, MGST2, leukotriene C4 synthase (LTC4S) and five lipoxygenase activating protein (FLAP) a second type and MGST3 exemplifies a third type. MGST2 is most similar to LTC4S and they share 44% sequence identity. 
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 2TMHs; (65-87),(105-127)
Bibliography 1.Ahmad S, Thulasingam M, Palombo I, Daley DO, Johnson KA, Morgenstern R, Haeggström JZ, Rinaldo-Matthis A. Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity. Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1365-71. doi: 10.1016/j.bbapap.2015.06.003. Epub 2015 Jun 9. PMID: 26066610.