Search by BoMiProt ID - Bomi707


Primary Information

BoMiProt ID Bomi707
Protein Name Catenin alpha-1
Organism Bos taurus
Uniprot IDQ3MHM6
Milk FractionWhey
Ref Sequence ID NP_001030443.1
Aminoacid Length 906
Molecular Weight 100133
FASTA Sequence Download
Gene Name CTNNA1
Gene ID 526848
Protein Existence Status Reveiwed:Experimental evidence at transcript level

Secondary Information

PTMs N-acetylation at Threonine, Isopeptide bond formation, Phosphorylation at Ser/Thr, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
Predicted Disorder Regions 1-84,263-289,318-327,632-906
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion.
Additional Comments mutations in α-catenin (CTNNA1) cause FEVR(Familial exudative vitreoretinopathy)by overactivating the β-catenin pathway and disrupting cell adherens junctions.
Bibliography 1.Zhu X, Yang M, Zhao P, Li S, Zhang L, Huang L, Huang Y, Fei P, Yang Y, Zhang S, Xu H, Yuan Y, Zhang X, Zhu X, Ma S, Hao F, Sundaresan P, Zhu W, Yang Z. Catenin α 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/β-catenin signaling. J Clin Invest. 2021 Mar 15;131(6):e139869. doi: 10.1172/JCI139869. PMID: 33497368; PMCID: PMC7954601.