Primary Information |
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BoMiProt ID | Bomi7046 |
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Protein Name | Methionine aminopeptidase 2/MAP 2/MetAP 2/Initiation factor 2-associated 67 kDa glycoprotein/p67/p67eIF2/Peptidase M |
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Organism | Bos taurus |
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Uniprot ID | Q3ZC89 |
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Milk Fraction | whey |
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Ref Sequence ID | NP_001035583.1 |
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Aminoacid Length | 477 |
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Molecular Weight | 52812 |
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FASTA Sequence |
Download |
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Gene Name | METAP2 |
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Gene ID | 404150 |
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Protein Existence Status | Reviewed |
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Secondary Information |
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Protein Function | It removes the N-terminal methionine from nascent proteins during translation. |
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Biochemical Properties | The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged |
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PTMs | Glycosylation, Acetylation and phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q3ZC89|MAP2_BOVIN Methionine aminopeptidase 2 OS=Bos taurus OX=9913 GN=METAP2 PE=2 SV=1
MAGVEEAASCGSHLNGDLDPDEREEGAASTAEEAAKKKKRKKKKS*45KGAATGQQEPDKEAG
AS*62*62VDEVTRQLERQALEEKEKDDDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPIC
DLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRK
YVMSWIKPGMTMIEICEKMEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTV
LQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVG
EAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVY
AIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLD
RLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
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Predicted Disorder Regions | (1-120) |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Significance of PTMs | O-glycosylation is required for EIF2S1 binding |
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Bibliography | Goya Grocin, A., Kallemeijn, W. W., & Tate, E. W. (2021). Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity. Trends in pharmacological sciences, 42(10), 870–882. https://doi.org/10.1016/j.tips.2021.07.004 |