Primary Information |
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| BoMiProt ID | Bomi7028 |
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| Protein Name | Mesoderm induction early response protein 2/Mi-er2 |
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| Organism | Bos taurus |
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| Uniprot ID | A5PJX4 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001092496.1 |
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| Aminoacid Length | 561 |
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| Molecular Weight | 61299 |
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| FASTA Sequence |
Download |
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| Gene Name | MIER2 |
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| Gene ID | 523726 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | functions as a transcriptional repressor through its ability to recruit HDAC1/2 activity |
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| Biochemical Properties | Enables RNA polymerase II-specific DNA-binding transcription factor binding |
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| PTMs | Phosphorylation at serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A5PJX4|MIER2_BOVIN Mesoderm induction early response protein 2 OS=Bos taurus OX=9913 GN=MIER2 PE=2 SV=1
MAEASSLERQS*11PGAASCLPHSLCPGEPNLQTTAVVSMGSADHQFHLAEILSQNYGVREEH
EGAAPGPEKPEEELEKDFVSQSSDMPLDELLALYGYETSDPISERESEGSDTAAHLPDMT
LDKDQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPSQSGSCFLADADKEPGSSSS
SDAEEDPLPANKCKKEIMVGPQFQADLSNLHSNRHGEKIYENEDQLLWDPNILPEREVEE
FLYRAVKRRWHEMAGSQLPEGEAVKDSEQALYELVKCNFNAEEALRRLRFNVKVIRDGLC
AWSEEERRNFEHGFRVHGKNFHLIQANKVRTRSVGECVEYYYLWKKSERYDYFSQQTRLG
RRKYGPSGNTDADQDLEGSDPDGPGRPRSSPPLPLPAAAHGPGPEHDRLAQMHTEPLSMG
SSMSRSLGEPGEALDVPPSSEPGPRLFPPLDEPSALPSSRRPPALAEPAFFPPATAAPEP
GASPRLAVDLTLPEELPLVSSHEDTDGEPEETVGPPQVALSVAEFGLIGIGDVNPFLASH
PACPASGLHSEPLSHCNVMTC |
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| Predicted Disorder Regions | 1-28, 52-188, 360-515 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. Ding Z, Gillespie LL, Paterno GD. Mol. Cell. Biol. 23, 250-8, (2003). View articlePMID: 12482978 |
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