Search by BoMiProt ID - Bomi7009


Primary Information

BoMiProt ID Bomi7009
Protein Name Melanoma-associated antigen D4/MAGE-D4 antigen
Organism Bos taurus
Uniprot IdA6QLI5
Milk FractionWhey
Ref Sequence Id NP_001096781.1
Aminoacid Length 740
Molecular Weight 81527
Fasta Sequence https://www.uniprot.org/uniprot/A6QLI5.fasta
Gene Name MAGED4
Gene Id 100125231
Protein Existence Status reviewed

Secondary Information

Protein Function  A potential biomarker for glioma and an important prognostic factor for patients with new or recurring glioma.It's overexpression influences tumor progression, and MADE-D4 can be a prognostic marker and a potential molecular target in squamous cell EC.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-12, 95-354, 369-382, 699-723
DisProt Annotation
TM Helix Prediction no TM helices
Additional Comments MAGE-D4 critically contributes to breast cancer tumorigenesis by regulating anchorage-independent growth, motility, and invasiveness.
Bibliography 1.Yan J, Wen J, Wei ZD, Li XS, Li P, Xiao SW. Prognostic and clinicopathological value of melanoma-associated antigen D4 in patients with glioma. Oncol Lett. 2018 Apr;15(4):4151-4160. doi: 10.3892/ol.2018.7884. Epub 2018 Jan 26. PMID: 29541180; PMCID: PMC5835852. 2.Oya H, Kanda M, Takami H, Hibino S, Shimizu D, Niwa Y, Koike M, Nomoto S, Yamada S, Nishikawa Y, Asai M, Fujii T, Nakayama G, Sugimoto H, Fujiwara M, Kodera Y. Overexpression of melanoma-associated antigen D4 is an independent prognostic factor in squamous cell carcinoma of the esophagus. Dis Esophagus. 2015 Feb-Mar;28(2):188-95. doi: 10.1111/dote.12156. Epub 2013 Oct 21. PMID: 24147998.