Primary Information |
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BoMiProt ID | Bomi7008 |
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Protein Name | Melanocyte protein PMEL |
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Organism | Bos taurus |
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Uniprot ID | Q06154 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001073684.2 |
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Aminoacid Length | 649 |
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Molecular Weight | 69366 |
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FASTA Sequence |
Download |
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Gene Name | PMEL |
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Gene ID | 281487 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | fibril formation within melanosomes during vertebrate melanogenesis. PMEL mutations were also found to alter pheomelanic pigmentation resulting in coat color dilution. |
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Significance in milk | melanogenesis |
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PTMs | N and O Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q06154|PMEL_BOVIN Melanocyte protein PMEL OS=Bos taurus OX=9913 GN=PMEL PE=2 SV=2
MDLVLRKYLLHVALMGVLLAVGTTEGPRDRDWLGVSRQLRIKAWNRQLYPEWTESQGPDC
WRGGHISLKVSNDGPTLIGAN*81ASFSIALHFPKSQKVLPDGQVIWAN*106NTIIN*111GSQVWGGQL
VYPQEPDDTCIFPDGEPCPSGPLSQKRCFVYVWKTWDQYWQVLGGPVSGLSIGTDKAMLG
TYNMEVTVYHRRGSQSYVPLAHSSSAFTITDQVPFSVSVSQLQALDGRNKRFLRKQPLTF
ALQLHDPSGYLAGADLSYTWDFGDSTGTLISRALTVTHTYLESGPVTAQVVLQAAIPLTS
CGSSPVPGTTDRHVTTAEAPGTTAGQVPTTEVMGTTPGQVPTAEAPGTTVGWVPTTEDVG
TTPEQVATSKVLSTTPVEMPTAKATGRTPEVSTREPSGTTVTQGTTPELVETTAGEVSTP
EPAGSN*426TSSFMPTEGTAGSLSPLPDDTATLVLEKRQAPLDCVLYRYGSFSLTLDIVQGIE
SAEILQAVSSSEGDAFELTVSCQGGLPKEACMDISSPGCQLPAQRLCQPVPPSPACQLVL
HQVLKGGSGTYCLN554VSLADANSLAMVSTQLVMPGQEAGLRQAPLFVGILLVLTALLLASL
IYRRRLMKQGSAVPLPQLPHGRTQWLRLPWVFRSCPIGESKPLLSGQQV
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Predicted Disorder Regions | 1 disordered segment; (295-453) |
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DisProt Annotation | |
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TM Helix Prediction | 1TMH ; (584-602) |
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Bibliography | Knaust J, Weikard R, Albrecht E, Brunner RM, Günther J, Kühn C. Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis. Genes (Basel). 2020 Jul 13;11(7):788. doi: 10.3390/genes11070788. PMID: 32668786; PMCID: PMC7397160. |