Search by BoMiProt ID - Bomi6915


Primary Information

BoMiProt ID Bomi6915
Protein Name Lysyl oxidase homolog 1/Lysyl oxidase-like protein 1
Organism Bos taurus
Uniprot IdQ95L39
Milk FractionWhey
Ref Sequence Id NP_776808.1
Aminoacid Length 591
Molecular Weight 64496
Fasta Sequence https://www.uniprot.org/uniprot/Q95L39.fasta
Gene Name LOXL1
Gene Id 281903
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells mainly located in smooth muscle cells and fibroblasts
Protein Function elastic fiber formation and remodeling.catalyse the covalent cross-linking of collagen and elastin through oxidative deamination of lysine or hydroxylysine side chains, particularly during dynamic processes such as development, tissue injury, fibrosis, and cancer
Biochemical Properties belongs to lysyl oxidase family oxidise amine to reactive aldehydes.Highly conserved c terminal region called copper binding catalytic domain which is responsible for converting primary amines of side chains of lysine into reactive aldehydes.N-terminal regions, which are important for substrate binding and enzyme maturation.
PTMs disulfide bond formation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 25-38, 94-98, 120-123, 146-148, 160-192, 233-256, 285-290, 302-309
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Schlötzer-Schrehardt U, Zenkel M. The role of lysyl oxidase-like 1 (LOXL1) in exfoliation syndrome and glaucoma. Exp Eye Res. 2019 Dec;189:107818. doi: 10.1016/j.exer.2019.107818. Epub 2019 Sep 26. PMID: 31563608.