|Protein Name||Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform|
|Ref Sequence Id||NP_851374.1|
|Amino Acid Lenth||309|
|Protein Existence Status||Reviewed: Experimental evidence at protein level|
|Presence in other biological fluids/tissue/cells||PP2A is highly conserved from yeast to humans;|
|Protein Function||Protein phosphatase activities regulate cellular metabolism and are attributed to two types: type 1, namely PP1, and type 2, which consisted of three enzymes called PP2A, PP2B, and PP2C; PP2A plays an important role in development, cell proliferation and death, cell mobility, cytoskeleton dynamics, the control of the cell cycle, and the regulation of numerous signaling pathways; important tumor suppressor|
|Biochemical Properties||PP2A exists in two general forms—a heterodimeric core enzyme and a heterotrimeric holoenzyme; PP2A core enzyme consists of a scaffold subunit (also known as the A or PR65 subunit) and a catalytic subunit (C subunit); the scaffold and the catalytic subunits each have two isoforms, α and β, with the α isoform being about 10-fold more abundant than the β isoform; PP2A core enzyme interacts with a variable regulatory subunit to assemble into a holoenzyme; the catalytic subunit of PP2A is the primary target of a number of potent tumor-inducing toxins, such as okadaic acid (OA) and microcystin-LR; OA has an inhibitory constant of approximately 0.1 nM for the phosphatase activity of PP2A|
|Significance in milk||involved in oxytocin signalling pathway- might regulate mammary gland development|
|Linking IDs||Bomi396 Bomi2533|
|Bibliography||1. Olsen, J. V, Blagoev, B., Gnad, F., Macek, B., Kumar, C., Mortensen, P., & Mann, M. (2006). Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell, 127(3), 635–648. https://doi.org/10.1016/j.cell.2006.09.026. |
2. MacKintosh, C., Beattie, K. A., Klumpp, S., Cohen, P., & Codd, G. A. (1990). Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Letters, 264(2), 187–192. https://doi.org/10.1016/0014-5793(90)80245-e.
3. Ingebritsen, T. S., & Cohen, P. (1983). The Protein Phosphatases Involved in Cellular Regulation. Eur J Biochem, 132(2), 255–261.