Primary Information |
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BoMiProt ID | Bomi6814 |
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Protein Name | LIM domain-containing protein ajuba |
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Organism | Bos taurus |
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Uniprot ID | E1BKA3 |
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Milk Fraction | Whey |
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Ref Sequence ID | NP_001179446.1 |
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Aminoacid Length | 548 |
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Molecular Weight | 57765 |
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FASTA Sequence |
Download |
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Gene Name | AJUBA |
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Gene ID | 519937 |
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Protein Existence Status | reviewed |
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Secondary Information |
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Protein Function | nucleocytoplasmic Shuttling.Ajuba is a new cytosolic component of the IL-1 signaling pathway modulating IL-1-induced NF-kappaB activation.Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. |
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Biochemical Properties | three tandemly arranged LIM domains in the C-terminal region.The LIM domain defines a unique double zinc finger structure found in a class of proteins involved in cell identity, differentiation, and growth control . The LIM motif,
CX2CX16–23HX2CX2CX2C-X16–21CX2C(D,H).Amino-terminal pre-LIM domain is abundant in glycine and
proline residues.There are two potential SH3 recognition motifs within the pre-LIM domain.pre-LIM domain of Ajuba interacts with the SH3 domains of
Grb2. |
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PTMs | Phosphorylation on Ser |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|E1BKA3|AJUBA_BOVIN LIM domain-containing protein ajuba OS=Bos taurus OX=9913 GN=AJUBA PE=3 SV=1
MERLGEKASRLLEKLRLSDSGSAKFGRRKGESSRSGSDGTPGPGKGRLSGLGGPRKSGPR
GAAGGPGDEPLEPAREQGPLDAERNPRGS*89FEVPRYEGSFPGGPPPSRALPLPQSLPPDFR
LETTAPALS*129PRSSFASSSASDAS*143KPSSPRGSLLLDGAGAGGAGGSRPCSNRTSGISMGYD
QRHGS*185PLPAGPCLFGPPLAGVPAGYSSGGVPSAYPELHAALDRLCAHRPAGFGCQESRHS
YPPALGSPGALAGAGVGATGPLERRGAQPGRHS*273VTGYGDCAAGARYQDELTALLRLTVGT
GGREAGVRGESAGIEASGLEEPPGAFVPEAARARIREPESREDYFGTCIKCNKGIYGQSN
ACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCGHLI
LEKILQAMGKSYHPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKSYAPKCAACGQPI
LPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRLSA
RQPPANYI
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Predicted Disorder Regions | 15-118, 128-163, 183-211, 224-277 |
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DisProt Annotation | |
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TM Helix Prediction | No TM helices |
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Bibliography | Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD. Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. Mol Cell Biol. 1999 Jun;19(6):4379-89. doi: 10.1128/MCB.19.6.4379. PMID: 10330178; PMCID: PMC104397. |