|Protein Name||1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1|
|Milk Fraction||Whey, Exosome|
|Ref Sequence Id||NP_777242.1|
|Amino Acid Lenth||1216|
|Protein Existence Status||Reviewed: Experimental evidence at protein level|
|Protein Function||class of phospholipases that cleaves phospholipids on the diacylglycerol (DAG) side of the phosphodiester bond producing DAGs and phosphomonoesters; constitutes an important step in the inositide signaling pathways; plays an important role in brain function and is thus associated with brain disorders; it regulates both cortical development and synaptic plasticity; participate in the differentiation and activation of immune cells that control both the innate and adaptive immune systems; linked to the development of myeloproliferative neoplasm in mice; specifi c key role in cell migration and invasion, therefore contributing to carcinogenesis|
|Biochemical Properties||calcium (Ca2+)-dependent phosphodiesterases; PI-PLCß enzymes are usually activated by G protein-coupled receptors; PI-PLCγ subtypes are commonly activated by receptor tyrosine kinase (RTK), via SH2 domain-phospho-tyrosine interaction; Most of PI-PLCß may have a high guanosine; triphosphatase activating protein (GAP) activity|
|Significance in milk||responsible for the hydrolyses of phospholipids of the MFG membrane, thereby affecting the stability of the cream emulsion;|
|Additional Comments||13 mammalian PLC isozymes identified so far are organized within 6 families: β(1–4), γ(1–2), δ(1,3,4), ε, ζ and η(1–2); phospholipase treatment of milk was found to reduce fat losses in whey and cooking water and to increase CY by improving fat and moisture retention in the cheese curd in Mozzarella cheese|
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