Primary Information
BoMiProt ID	Bomi6739
Protein Name	Leucine carboxyl methyltransferase 1/[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
Organism	Bos taurus
Uniprot ID	Q3T0H0
Milk Fraction	Whey
Ref Sequence ID	NP_001069956.1
Aminoacid Length	332
Molecular Weight	38009
FASTA Sequence	Download
Gene Name	LCMT1
Gene ID	618021
Protein Existence Status	reviewed
Secondary Information
Protein Function	LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development in mice.
Biochemical Properties	Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
PTMs	Methylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	(1-16)
DisProt Annotation
TM Helix Prediction	No TM helices
Significance of PTMs	methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells
Linking IDs
Bibliography	1.Sontag JM, Nunbhakdi-Craig V, Sontag E. Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells. J Biol Chem. 2013 Sep 20;288(38):27396-27405. doi: 10.1074/jbc.M113.490102. Epub 2013 Aug 13. PMID: 23943618; PMCID: PMC3779734. 2.Jocelyn A. Lee, David C. Pallas, Leucine Carboxyl Methyltransferase-1 Is Necessary for Normal Progression through Mitosis in Mammalian Cells*, Journal of Biological Chemistry, Volume 282, Issue 42, 2007, Pages 30974-30984, ISSN 0021-9258, https://doi.org/10.1074/jbc.M704861200.