Search by BoMiProt ID - Bomi6739


Primary Information

BoMiProt ID Bomi6739
Protein Name Leucine carboxyl methyltransferase 1/[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1
Organism Bos taurus
Uniprot IdQ3T0H0
Milk FractionWhey
Ref Sequence Id NP_001069956.1
Aminoacid Length 332
Molecular Weight 38009
Fasta Sequence https://www.uniprot.org/uniprot/Q3T0H0.fasta
Gene Name LCMT1
Gene Id 618021
Protein Existence Status reviewed

Secondary Information

Protein Function  LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development in mice.
Biochemical Properties Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
PTMs Methylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions (1-16)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells
Linking IDs
Bibliography 1.Sontag JM, Nunbhakdi-Craig V, Sontag E. Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells. J Biol Chem. 2013 Sep 20;288(38):27396-27405. doi: 10.1074/jbc.M113.490102. Epub 2013 Aug 13. PMID: 23943618; PMCID: PMC3779734. 2.Jocelyn A. Lee, David C. Pallas, Leucine Carboxyl Methyltransferase-1 Is Necessary for Normal Progression through Mitosis in Mammalian Cells*, Journal of Biological Chemistry, Volume 282, Issue 42, 2007, Pages 30974-30984, ISSN 0021-9258, https://doi.org/10.1074/jbc.M704861200.