Search by BoMiProt ID - Bomi6707


Primary Information

BoMiProt ID Bomi6707
Protein Name Lanosterol synthase/2,3-epoxysqualene--lanosterol cyclase/Oxidosqualene--lanosterol cyclase
Organism Bos taurus
Uniprot IdP84466
Milk FractionExosomes,MFGM
Ref Sequence Id NP_001040029.1
Aminoacid Length 732
Molecular Weight 83184
Fasta Sequence https://www.uniprot.org/uniprot/P84466.fasta
Gene Name LSS
Gene Id 615906
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells liver
Protein Function Lanosterol synthase (LS) is a key enzyme involved in the mevalonate pathway (MVA pathway) to produce lanosterol, which is a precursor for synthesizing S. baumii triterpenoids.
PTMs N-acetylation at Thr
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Lanosterol synthase (LSS) abnormity contributes to lens opacity in rats, mice, dogs, and human congenital cataract development. 
Bibliography 1.Wu TK, Huang CY, Ko CY, Chang CH, Chen YJ, Liao HK. Purification, tandem mass characterization, and inhibition studies of oxidosqualene-lanosterol cyclase enzyme from bovine liver. Arch Biochem Biophys. 2004 Jan 1;421(1):42-53. doi: 10.1016/j.abb.2003.09.036. PMID: 14678783. 2.Shen X, Zhu M, Kang L, Tu Y, Li L, Zhang R, Qin B, Yang M, Guan H. Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract. J Ophthalmol. 2018 Jul 11;2018:4125893. doi: 10.1155/2018/4125893. PMID: 30116630; PMCID: PMC6079410. 3.Wang XT, Sun TT, Sun J, Wang S, Zou L. Expression Analysis of Lanosterol synthase Gene in Dynamic Accumulation of Triterpenoids in Sanghuangporus baumii. Protein Pept Lett. 2021 Sep 21. doi: 10.2174/0929866528666210922103059. Epub ahead of print. PMID: 34551686.