Primary Information |
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| BoMiProt ID | Bomi6663 |
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| Protein Name | Kinesin-like protein KIF22 |
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| Organism | Bos taurus |
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| Uniprot Id | A6QPL4 |
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| Milk Fraction | Whey,exosome |
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| Ref Sequence Id | NP_001095338.2 |
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| Aminoacid Length | 662 |
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| Molecular Weight | 73202 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/A6QPL4.fasta |
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| Gene Name | KIF22 |
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| Gene Id | 506294 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | It is a kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. It binds to microtubules and to DNA and also has a role in congression of laterally attached chromosomes in NDC80-depleted cells. |
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| PTMs | Phosphorylation and Ubiquitinylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A6QPL4|KIF22_BOVIN Kinesin-like protein KIF22 OS=Bos taurus OX=9913 GN=KIF22 PE=2 SV=2
MDAGLPARRRREMAAAISGAGRCRLSKVGAGRRPPPARVRVAVRLRPFVDGTAGENDTPC
VRGLDSCSLEIANWRNHQETLKYQFDAFYGERSSQQDIYAGSVQPILRHLLEGQNASVLA
YGPTGAGKTHTMLGSPEQPGVIPRALMDLLQLTREEGAEGRPWALSVTMSYLEIYQEKVL
DLLEPSSGDLVIREDCRGNILIPGLTQKPITSFADFERHFLPASRNRTVGATRLNQRSSR
SHAVLLVKVDQRERLAPFRQREGKLYLIDLAGSEDNRRTGNKGLRLKESGAINTSLFVLG
KVVDALNQGLPRVPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYLDTVSALNFAARS
KEVINRPFTNESLQLPVLAPVKLSQKELLGPSEAKRARGPEEEETES*407PELPIAPASASQK
LS*422PLQKLSSMDPAMLERLLSLDRLLGS*447QGSQGTPLLSTPKRERMVLMKTVEEKDLEIERL
KMKQKELEAKVLAQEAADPKEKENYSTTMLRPLARRTVTVAKPLKKAVVMPLQLIQEQAA
S*541PNAKIHILKKKGRKRKLES*560LDASQPEKAEDGWELQIS*578PELLAHGRQKILDLLNEGSARD
LRSLQRIGQKKAQLIVGWRELHGPFSQVEDLERVEGISGKQMESFLKANILGLAAGQGCG
PS
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| Predicted Disorder Regions | 1-34, 401-425, 517-524, 544-562 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | Ubiquitination is brought about by SIAH1 which leads to its subsequent proteasomal degradation. |
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| Bibliography | Zhang, Z., Xie, H., Zhu, S., Chen, X., Yu, J., Shen, T., Li, X., Shang, Z., & Niu, Y. (2018). High Expression of KIF22/Kinesin-Like DNA Binding Protein (Kid) as a Poor Prognostic Factor in Prostate Cancer Patients. Medical science monitor : international medical journal of experimental and clinical research, 24, 8190–8197. https://doi.org/10.12659/MSM.912643 |
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