Search by BoMiProt ID - Bomi662


Primary Information

BoMiProt ID Bomi662
Protein Name CD81 antigen
Organism Bos taurus
Uniprot IdQ3ZCD0
Milk FractionMFGM, Exosome
Ref Sequence Id NP_001030271.1
Amino Acid Lenth 236
Molecular Weight 25854
Fasta Sequence https://www.uniprot.org/uniprot/Q3ZCD0.fasta
Gene Name CD81
Gene Id 511435
Protein Existence Status Reveiwed:Experimental evidence at transcript level

Secondry Information

Presence in other biological fluids/tissue/cells Expressed on most human tissues with the notable exceptions of red blood cells and platelets
Protein Function Reported to influence adhesion, morphology, activation, proliferation, and differentiation of B, T, and other cells; T cells CD81 associates with CD4 and CD8 and provides a costimulatory signal with CD3; physically and functionally associated with several integrins
Biochemical Properties Four transmembrane domain membrane protein of the tetraspanin (TSP) superfamily
Significance in milk Marker of mammary extracellular vesicles
Bibliography 1. Zimmerman B, Kelly B, McMillan BJ, Seegar TCM, Dror RO, Kruse AC, et al. Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell. 2016 Nov 3;167(4):1041-1051.e11.