Primary Information |
|---|
| BoMiProt ID | Bomi661 |
|---|
| Protein Name | Platelet glycoprotein 4 |
|---|
| Organism | Bos taurus |
|---|
| Uniprot Id | P26201 |
|---|
| Milk Fraction | Whey, MFGM, Exosome |
|---|
| Ref Sequence Id | NP_001265550.1 |
|---|
| Amino Acid Lenth | 472 |
|---|
| Molecular Weight | 52940 |
|---|
| Fasta Sequence | https://www.uniprot.org/uniprot/P26201.fasta |
|---|
| Gene Name | CD36 |
|---|
| Gene Id | 281052 |
|---|
| Protein Existence Status | Reveiwed:Experimental evidence at protein level |
|---|
Secondry Information |
|---|
| Protein Function | Serves as a ligand receptor of thrombospondin, long chain fatty acids, oxidized low density lipoproteins (LDLs) and malaria-infected erythrocytes; receptor for von Willebrand factor (vWF), which plays a crucial role in primary hemostasis; |
|---|
| Significance in milk | Most abundant glycoprotein in buffalo MFGM; resposible for host immunity |
|---|
Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P26201|CD36_BOVIN Platelet glycoprotein 4 OS=Bos taurus OX=9913 GN=CD36 PE=1 SV=5
MGCNRNCGLIAGAVIGAVLAVFGGILMPVGDMLIEKTIKKEVVLEEGTIA
FKNWVKTGTDVYRQFWIFDVQNPDEVTVN*79SSKIKVKQRGPYTYRVRYLAK
EN*102ITQDPETHTVSFLQPNGAIFEPSLSVGTEDDTFTILNLAVAAAPQLYP
NTFMQGILNSFIKKSKSSMFQN*172RTLKELLWGYTDPFLNLVPYPITTTIGV
FYPYN*205NTADGIYKVFNGKDDISKVAIIDTYKGRKN*235LSYWSSYCDLIN*247GTD
AASFPPFVEKTRVLQFFSSDICRSIYAVFGAEINLKGIPVYRFILPSFAF
ASPFQNPDNHCFCTEKIISKN*321CTLYGVLDIGKCKEGKPVYISLPHFLHGS
PELAEPIESLSPNEEEHSTYLDVEPITGFTLRFAKRLQVNMLVKPAKKIE
ALKNLKHNYIVPILWLN*417ETGTIGDEKAEMFRNQVTGKINLLGLVEIVLLS
VGVVMFIAFMISYCACRSKRVN
|
|---|
| Bibliography | 1. Hwangbo S, Azuma N, Kurisaki J, Kanno C. Purification and Characterization of Novel Whey Glycoprotein WGP-88 Which Binds to a Monoclonal Antibody to PAS-4 Glycoprotein in the Bovine Milk Fat Globule Membrane. Biosci Biotechnol Biochem. 1997;61(9):1568–74.
2. Nguyen HTH, Ong L, Hoque A, Kentish SE, Williamson N, Ang CS, et al. A proteomic characterization shows differences in the milk fat globule membrane of buffalo and bovine milk. Food Biosci. 2017 Sep 1;19:7–16.
3. Holmes RS. Comparative studies of vertebrate platelet glycoprotein 4 (CD36). Vol. 2, Biomolecules. MDPI AG; 2012. p. 389–414. |
|---|
