Primary Information |
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| BoMiProt ID | Bomi6587 |
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| Protein Name | Kelch domain-containing protein 8B |
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| Organism | Bos taurus |
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| Uniprot Id | Q5E9V5 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_001030447.2 |
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| Aminoacid Length | 354 |
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| Molecular Weight | 37540 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/Q5E9V5.fasta |
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| Gene Name | KLHDC8B |
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| Gene Id | 527321 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis.Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells . |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | no TM helices |
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| Bibliography | Krem MM, Luo P, Ing BI, Horwitz MS. The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability. J Biol Chem. 2012 Nov 9;287(46):39083-93. doi: 10.1074/jbc.M112.390088. Epub 2012 Sep 17. PMID: 22988245; PMCID: PMC3493949. |
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