Search by BoMiProt ID - Bomi6586


Primary Information

BoMiProt ID Bomi6586
Protein Name Kelch domain-containing protein 2
Organism Bos taurus
Uniprot IdQ5E9A7
Milk FractionWhey
Ref Sequence Id NP_001014948.1
Aminoacid Length 406
Molecular Weight 46125
Fasta Sequence https://www.uniprot.org/uniprot/Q5E9A7.fasta
Gene Name KLHDC2
Gene Id 535436
Protein Existence Status reviewed

Secondary Information

Protein Function mKlhdc2 plays an essential role in muscle cell migration and differentiation, potentially by acting on the cytoskeleton remodeling of myoblasts
Biochemical Properties It belongs to the family of Kelch domain containing proteins, which are known to be involved in such diverse biological functions as transcriptional activation or repression, actin remodeling or stabilization and cell adhesion.In the case of mKlhdc2, the propeller consists of six β-sheets and essentially covers the whole protein, with no other motives detectable by database searches. mKlhdc2 shows the highest homology to its human orthologue hKlhdc2 (also named HCLP1,and host cell factor 1 (HCF1). mKlhdc2 and hKlhdc2 are 79% identical on the nucleotide level and 96% identical on the protein level.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts.
Bibliography 1.Neuhaus P, Jaschinsky B, Schneider S, Neuhaus H, Wolter A, Ebelt H, Braun T. Overexpression of Kelch domain containing-2 (mKlhdc2) inhibits differentiation and directed migration of C2C12 myoblasts. Exp Cell Res. 2006 Oct 1;312(16):3049-59. doi: 10.1016/j.yexcr.2006.06.006. Epub 2006 Jun 15. PMID: 16860314. 2.] H.J. Zhou, C.M. Wong, J.H. Chen, B.Q. Qiang, J.G. Yuan, D. Jin, Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein, J. Biol. Chem. 276 (2001) 28933–28938. 3. J. Adams, R. Kelso, L. Cooley, The kelch repeat superfamily of proteins: propellers of cell function, Trends Cell Biol. 10 (2000) 17–24.