Primary Information
BoMiProt ID	Bomi6585
Protein Name	Kelch domain-containing protein 10
Organism	Bos taurus
Uniprot ID	Q0IIC2
Milk Fraction	Whey
Ref Sequence ID	NP_001068695.1
Aminoacid Length	442
Molecular Weight	49111
FASTA Sequence	Download
Gene Name	KLHDC10
Gene ID	505844
Protein Existence Status	reviewed
Secondary Information
Protein Function	This protein participates in the oxidative stress-induced cell death through MAP3K5 activation. It acts as a regulator of necroptosis. It is a substrate-recognition component of a CRL2 E3 ubi-protein ligase complex of the DesCEND pathway and is involved in pathway protein ubiquitination.
Biochemical Properties	composed of the kelch repeat domain that consists of six repeated kelch motifs.KLHDC10 Interacts with PP5 through Phosphatase Domain of PP5.KLHDC10 Is Required for H2O2-Induced sustained activation of ASK1 and cell death.
PTMs	Methylation
Site(s) of PTM(s) N-glycosylation, O-glycosylation, Phosphorylation	NA
Predicted Disorder Regions	(1-40), (54-58)
DisProt Annotation
TM Helix Prediction	No TM helices
Bibliography	Sekine, Y., Hatanaka, R., Watanabe, T., Sono, N., Iemura, S., Natsume, T., Kuranaga, E., Miura, M., Takeda, K., & Ichijo, H. (2012). The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. Molecular cell, 48(5), 692–704. https://doi.org/10.1016/j.molcel.2012.09.018