Primary Information |
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| BoMiProt ID | Bomi65 |
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| Protein Name | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase |
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| Organism | Bos taurus |
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| Uniprot ID | Q3ZBL1 |
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| Milk Fraction | Exosome |
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| Ref Sequence ID | NP_001030545.1 |
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| Aminoacid Length | 179 |
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| Molecular Weight | 21487 |
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| FASTA Sequence |
Download |
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| Gene Name | ADI1 |
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| Gene ID | 615764 |
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| Protein Existence Status | Reviewed: Experimental evidence at transcript level |
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Secondary Information |
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| Protein Function | isozyme from the methionine salvage pathway; N-terminal truncated version of human ARD is implicated in the replication of hepatitis C virus in non-permissive cell lines |
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| Biochemical Properties | mammalian ARD also exhibits metal ion-dependent on- and off-pathway chemistry in vitro; as found in rats, Fe2+-bound ARD exhibits ~ 10 times higher enzymatic activity than Ni2+, Co2+ or Mn2+ bound ARD; Fe-ARD requires anaerobic handling due to oxidation from the Fe+2 to Fe+3 state |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | gene ADI1 encoding ARD is downregulated in rat prostate and human prostate cancer cell lines and its enforced expression was shown to induce apoptosis |
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| Bibliography | 1. Deshpande, A. R., Wagenpfeil, K., Pochapsky, T. C., Petsko, G. A., & Ringe, D. (2016). Metal-Dependent Function of a Mammalian Acireductone Dioxygenase. Biochemistry, 55(9), 1398–1407. https://doi.org/10.1021/acs.biochem.5b01319 |
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