Search by BoMiProt ID - Bomi6455


Primary Information

BoMiProt ID Bomi6455
Protein Name Interferon alpha-inducible protein 6
Organism Bos taurus
Uniprot IdQ6IED8
Milk FractionWhey,MFGM
Ref Sequence Id NP_001069056.1
Aminoacid Length 134
Molecular Weight 13992
Fasta Sequence https://www.uniprot.org/uniprot/Q6IED8.fasta
Gene Name IFI6
Gene Id 512913
Protein Existence Status reviewed

Secondary Information

Protein Function Increased expression of IFI6 has been associated with the anti-apoptotic activity of IFN-α2b.FI6 is a mitochondria-targeted protein, inhibits the release of cytochrome c from mitochondria and delays the apoptotic process initiated and transduced by the TNF-related apoptosis-inducing ligand/caspase 8 pathway. IFI6, via E2F2 regulates DNA replication and melanoma development and growth. impairs EGFR activation by CD81 and inhibits hepatitis C virus infection.
PTMs Glycosylated.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 3 disordered segments; (24-38), (83-86), (118-134)
DisProt Annotation
TM Helix Prediction 3TMHs ; (41-63),(70-92) and (101-119)
Bibliography Meyer K, Kwon YC, Liu S, Hagedorn CH, Ray RB, Ray R. Interferon-α inducible protein 6 impairs EGFR activation by CD81 and inhibits hepatitis C virus infection. Sci Rep. 2015 Mar 11;5:9012. doi: 10.1038/srep09012. PMID: 25757571; PMCID: PMC4355636.