Primary Information |
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| BoMiProt ID | Bomi6451 |
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| Protein Name | Inter-alpha-trypsin inhibitor heavy chain H5/ITI heavy chain H5/ITI-HC5/Inter-alpha-inhibitor heavy chain 5 |
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| Organism | Bos taurus |
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| Uniprot Id | A2VE29 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_001095986.1 |
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| Aminoacid Length | 940 |
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| Molecular Weight | 104356 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/A2VE29.fasta |
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| Gene Name | ITIH5 |
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| Gene Id | 534787 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Interacts with HA(Hyaluronan),participate in ECM stabilization and epidermal differentiation,also modulating epidermal differentiation. |
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| PTMs | Glycosylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A2VE29|ITIH5_BOVIN Inter-alpha-trypsin inhibitor heavy chain H5 OS=Bos taurus OX=9913 GN=ITIH5 PE=2 SV=1
MLPLLGLCFALPLCAGLLEEARSWEDTSDQVGLRIPRQVRLLQRLKTKPLMTEFSVKSTI
ISRYAFTTVACRMLNRGSEDQEVTFQMQIPAAAFITN*97FTALIGDKVYQGEITEREKRNGD
KVKEKRN*127KTIEDNGEKGTETFRASAVLPSKDKAAFLLSYEELLQRRLGKYEHVVSVRPQQ
LVGRLTVEVTVLERPGIAELEVLGLQNSRQRGSGRGPDDSGPPPSTVINQN*231ETFAKVVFK
PSVVQQAKIAQNGILGDFIVRYDVNREQSIGDIQVLDGYFVHYFAPKDLPPLPKNVVFVL
DSSASMVGTKLRQTKDALFTILHDLRPQDHFNIVGFSNRIKVWKDHLVSVTPNSIRDGKV
YIHHMSPSGGTDINGALQRGIQLLNDYVAHNDIEDRSVSLVVFLTDGKPTVGETHTFKIL
N*421NTREATRGRVCIFTVGIGADVDFKLLEKLSLENCGLTRRVHEDHDARAQLIGFYDEIRT
PLLSDIRVDYPPSLVERATRTLFPNYFN*508GSEIVIAGKLVDRAMDRLHVEVTASNSKKFVV
LKKDVPVEPRKVGIDVSQSPRPRGRGQEEPNHLERLWSYLTLKELLSAWLQSIEEPERER
LRQEAQALAVNHHFLIPFTSMTLKSAPRTEAPEAAYGMSSTSMATGPETVMQSLRGTHLQ
PGPAVKKPYNPRIKISKTSADGDPHFVVDFPLSN*694LTVCFNIDGEPGHILRLVSDHADSGV
TVNGELIGAPAPPNGHKKQRTYFRTITILVNKPERSYLEITPSRVIVDGGDRLVLPCN*778QS
AVVGRRGLEVSVSAN*795ASVTISIQGTVAFVVLLHLYKKPAPYQRNHLGFYIANGQGLSSNC
HGLLGQFLNQEARLIGLSKSPAHPPVPEAGERSEAVLEVKGRQVPVVWKQRRIYNGEEQV
DCWFARNNAAGLIDGEYKGYLAAHPFDSETAFGPGLSQGL
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.Huth S, Huth L, Marquardt Y, Fietkau K, Dahl E, Esser PR, Martin SF, Heise R, Merk HF, Baron JM. Inter-α-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a Natural Stabilizer of Hyaluronan That Modulates Biological Processes in the Skin. Skin Pharmacol Physiol. 2020;33(4):198-206. doi: 10.1159/000509371. Epub 2020 Aug 14. PMID: 32799206. |
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