Primary Information |
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| BoMiProt ID | Bomi6449 |
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| Protein Name | Inter-alpha-trypsin inhibitor heavy chain H3/
ITI heavy chain H3/ITI-HC3/Inter-alpha-inhibitor heavy chain 3 |
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| Organism | Bos taurus |
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| Uniprot ID | P56652 |
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| Milk Fraction | Whey |
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| Ref Sequence ID | NP_001095368.1 |
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| Aminoacid Length | 891 |
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| Molecular Weight | 99551 |
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| FASTA Sequence |
Download |
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| Gene Name | ITIH3 |
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| Gene ID | 508355 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Serves as Novel Diagnostic Biomarkers in Human Colorectal Cancer |
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| Biochemical Properties | ITI is a glycoprotein composed of three polypeptides: two heavy chains (HC1 and HC2) and one light chain (bikunin).Unlike the majority of plasma protein a non-disulfide covalent linkage exists between heavy chains and bikunin. |
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| Significance in milk | an acute phase protein |
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| PTMs | N-linked glycosylation at Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P56652|ITIH3_BOVIN Inter-alpha-trypsin inhibitor heavy chain H3 OS=Bos taurus OX=9913 GN=ITIH3 PE=1 SV=2
MALAQWPYLILALLSGLAVSGFPRNPSLLLGKRSLPGRAVDGIEVYSTKVNCKVTSRFAH
NVVTTRAVNHANTAKEVSFDVELPKTAFITN*91FTLTIDGVTYPGKVKEKEVAKKQYEKAVS
QGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEMYLKVQPKQLVK
HFEITVDIFEPQGISTLDAEASFITNDLLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCT
DSLLKGDFIITYDVNRESPANVQIVNGYFVHFFAPQGLPVVPKSVVFVIDVSGSMHGRKM
EQTKDALLKILEDVKQDDYLNFILFSGDVTTWKDSLVPATPENIQEASKFVMDIQDRGMT
NINDALLRGISMLNKAREEHTVPERSTSIIIMLTDGDANVGESRPEKIQENVRNAIGGKF
PLYNLGFGNNLNYNFLENMALENHGLARRIYEDSDANLQLQGFYEEVANPLLTGVEVEYP
QNAILDLTQNSYQHFYDGSEIVVAGRLADEDMNSFKAAVKGHGAINDLTFTEEVDMKEME
KALQERDYIFGDYIERLWAYLTIEQLLDKRKNAQGEEKEILTAQALELSLKYHFVTPLTS
MVVTKPEDNENQTAIANKPGEGPLDAEEVPSMAYLTSYQAPQTPYYYVDGDPHFIIQIPE
KDDAICFNIDEDPGTVLRLIQDPVTGLTVNGQIIGEKTGRSDSQTRRTYFGKLGIASAQM
DFRIEVTRENITLWNGDSLSTFSWLDTVMVTQDGLSVMINRKKNMVVSFGDGVTFVVVLH
QVWKKEPAHHDFLGFYVVNSRGMSAQTHGLLGQFFHPFDFQVSDVHPGSDPTKPDATMVV
KNHQLTVTRGSQKDYRKDISVGRNVACWFVHNNGQGLIDGIHRDYIVPNLF |
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| Predicted Disorder Regions | 611-624, 828-835 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Significance of PTMs | The glycosylated form of the bikunin corresponds to the urinary trypsin inhibitor (UTI), an ITI derivative. |
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| Additional Comments | ITI-related proteins might be considered as HA-binding proteins (HABP). The ITI related proteins are composed of four polypeptides (HC1, HC2, HC3 and the bikunin) encoded by four genes H1, H2, H3 and L. |
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| Bibliography | 1.Jiang X, Bai XY, Li B, Li Y, Xia K, Wang M, Li S, Wu H. Plasma Inter-Alpha-Trypsin Inhibitor Heavy Chains H3 and H4 Serve as Novel Diagnostic Biomarkers in Human Colorectal Cancer. Dis Markers. 2019 Jul 31;2019:5069614. doi: 10.1155/2019/5069614. PMID: 31481982; PMCID: PMC6701429. 2.Bost F, Diarra-Mehrpour M, Martin JP. Inter-alpha-trypsin inhibitor proteoglycan family--a group of proteins binding and stabilizing the extracellular matrix. Eur J Biochem. 1998 Mar 15;252(3):339-46. doi: 10.1046/j.1432-1327.1998.2520339.x. PMID: 9546647. |
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