Search by BoMiProt ID - Bomi6339


Primary Information

BoMiProt ID Bomi6339
Protein Name Hydroxylysine kinase/5-hydroxy-L-lysine kinase/Aminoglycoside phosphotransferase domain-containing protein 1
Organism Bos taurus
Uniprot IdA5PJU6
Milk FractionWhey
Ref Sequence Id NP_001092517.1
Aminoacid Length 376
Molecular Weight 42077
Fasta Sequence https://www.uniprot.org/uniprot/A5PJU6.fasta
Gene Name HYKK/AGPHD1
Gene Id 530270
Protein Existence Status reviewed

Secondary Information

Protein Function involved in lysine metabolism.Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.
Biochemical Properties this enzyme belong to transferases. catalyze the GTP-dependent phosphorylation of 5-hydroxy-l-lysine.The phosphorylation product made by this enzyme was metabolized by AGXT2L2, which converted it to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. AGXT2L1 catalyzed a similar reaction on phosphoethanolamine, converting it to ammonia, inorganic phosphate, and acetaldehyde.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions (1-16)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Veiga-da-Cunha M, Hadi F, Balligand T, Stroobant V, Van Schaftingen E. Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. J Biol Chem. 2012 Mar 2;287(10):7246-55. doi: 10.1074/jbc.M111.323485. Epub 2012 Jan 12. PMID: 22241472; PMCID: PMC3293546.