Search by BoMiProt ID - Bomi6315


Primary Information

BoMiProt ID Bomi6315
Protein Name Homeobox protein MSX-1/Msh homeobox 1-like protein
Organism Bos taurus
Uniprot IdO02786
Milk FractionWhey
Ref Sequence Id NP_777223.1
Aminoacid Length 303
Molecular Weight 31668
Fasta Sequence https://www.uniprot.org/uniprot/O02786.fasta
Gene Name MSX1
Gene Id 286872
Protein Existence Status reviewed

Secondary Information

Protein Function transcriptional repressor inhibits BMP 2 and BMP 4 and lymphoid enhancer-binding factor 1 via Wnt/β-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. Participate in limb-pattern formation and tooth formation.
PTMs Isopeptide bond formation, Ubl conjugation,SUMOylation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1 long disordered segment; (2-179)
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments Suppression of the transcription factor MSX1 gene delays bovine preimplantation embryo development in vitro
Bibliography Feng XY, Wu XS, Wang JS, Zhang CM, Wang SL. Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/β-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. Eur J Oral Sci. 2018 Feb;126(1):1-12. doi: 10.1111/eos.12390. Epub 2017 Nov 17. PMID: 29148101.