Search by BoMiProt ID - Bomi6292


Primary Information

BoMiProt ID Bomi6292
Protein Name Histone H4/H4.1
Organism Bos taurus
Uniprot IdP62803
Milk FractionWhey,Casein
Ref Sequence Id NP_001093194.1
Aminoacid Length 103
Molecular Weight 11367
Fasta Sequence https://www.uniprot.org/uniprot/P62803.fasta
Gene Id 280691 526789 527645 530773 617875
Protein Existence Status Reviewed

Secondary Information

Protein Function Core component of nucleosome.
PTMs Acetylation, Citrullination, Hydroxylation, Isopeptide bond formation, Methylation, Phosphorylation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|P62803|H4_BOVIN Histone H4 OS=Bos taurus OX=9913 PE=1 SV=2 MS*2GRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRIS*48GLIY*52EETRGVLK VFLENVIRDAVTYTEHAKRKT*81VTAMDVVY*89ALKRQGRTLYGFGG
Predicted Disorder Regions 1-42, 101-103
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Methylation of H4-Lys-20 generally correlates with transcriptional repression.H4K16 is the first lysine to be acetylated after replication which is important for recruiting Suv39h1 and G9a to the histone tails.H4K79 methylation is associated with gene silencing.Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.Phosphorylated by PAK2 at Ser-48 (H4S47ph). This phosphorylation increases the association of H3.3-H4 with the histone chaperone HIRA, thus promoting nucleosome assembly of H3.3-H4 and inhibiting nucleosome assembly of H3.1-H4.
Bibliography 1.Robin, P., Fritsch, L., Philipot, O. et al. Post-translational modifications of histones H3 and H4 associated with the histone methyltransferases Suv39h1 and G9a. Genome Biol 8, R270 (2007). https://doi.org/10.1186/gb-2007-8-12-r270