Search by BoMiProt ID - Bomi6291


Primary Information

BoMiProt ID Bomi6291
Protein Name Histone H3.2
Organism Bos taurus
Uniprot IdP84227
Milk FractionWhey,Casein
Ref Sequence Id NP_001160041.1
Aminoacid Length 136
Molecular Weight 15388
Fasta Sequence https://www.uniprot.org/uniprot/P84227.fasta
Gene Name N/A
Gene Id 504599 788077
Protein Existence Status reviewed

Secondary Information

Protein Function Core component of nucleosome which play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. H3.2 are expressed only in S-phase.
PTMs Acetylation, ADP-ribosylation, Citrullination, Hydroxylation, Lipidation, Methylation, Palmitoylation, Phosphorylation, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-55, 115-136
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).Mono methylation on Lys of TK4QTAR which is imp for transcriptional activation.andMono,Di and Tri-methylation K9STGGKAPR which is imp for transcriptional silencing.Acetylation on Lys of KSTGGK14APR which is imp for transcriptional activation.H3.2 is enriched in Lys27 di- and trimethylation. These generally repressive marks have been associated with gene silencing and the formation of facultative heterochromatin.
Bibliography 1.Hake SB, Garcia BA, Duncan EM, Kauer M, Dellaire G, Shabanowitz J, Bazett-Jones DP, Allis CD, Hunt DF. Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem. 2006 Jan 6;281(1):559-68. doi: 10.1074/jbc.M509266200. Epub 2005 Nov 2. PMID: 16267050.