Search by BoMiProt ID - Bomi6290


Primary Information

BoMiProt ID Bomi6290
Protein Name Histone H3.1
Organism Bos taurus
Uniprot IdP68432
Milk FractionWhey
Ref Sequence Id XP_002697506.1
Aminoacid Length 136
Molecular Weight 15404
Fasta Sequence https://www.uniprot.org/uniprot/P68432.fasta
Gene Id 107131750
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells testis
Protein Function Citrullination of extracellular histone H3.1 reduces antibacterial activity and exacerbates its proteolytic degradation
PTMs Acetylation, ADP-ribosylation, Citrullination, Hydroxylation, Methylation, Phosphoprotein, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-55, 114-136
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.Citrullination at Arg-9 and 18 by PADI4 impairs methylation and represses transcription.Phosphorylation at Thr-12 by PKN1 is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C.
Bibliography 1.Tanner L, Bhongir RKV, Karlsson CAQ, Le S, Ljungberg JK, Andersson P, Andersson C, Malmström J, Egesten A, Single AB. Citrullination of extracellular histone H3.1 reduces antibacterial activity and exacerbates its proteolytic degradation. J Cyst Fibros. 2021 Mar;20(2):346-355. doi: 10.1016/j.jcf.2020.07.010. Epub 2020 Jul 26. PMID: 32727663.