Search by BoMiProt ID - Bomi6279


Primary Information

BoMiProt ID Bomi6279
Protein Name Histone H1.1/Histone H1a
Organism Bos taurus
Uniprot IDG3N131
Milk FractionWhey,Casein
Ref Sequence ID XP_010816821.1
Aminoacid Length 218
Molecular Weight 22100
FASTA Sequence Download
Gene Name H1-1/HIST1H1A
Gene ID 618164
Protein Existence Status reviewed

Secondary Information

Protein Function Participate in chromatin condensation.H1 histones bind to linker DNA between nucleosomes
PTMs Acetylation, Citrullination, Hydroxylation, Phosphoprotein
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|G3N131|H11_BOVIN Histone H1.1 OS=Bos taurus OX=9913 GN=H1-1 PE=1 SV=1 MS*2EVALPAPAAS*12TSPEKPSAGKKAKKPAKAAAAAKKKPAGPSVS*44ELIVQAVSSSKERSGV SLAALKKALAAAGYDVEKNNSRIKLGLKSLVGKGTLVQTKGTGASGS*107FKLNKKVASVDAK PTATKVATKTKVTSASKKPKKASGAAAAKKSVKTPKKARKSVLTKKSSKSPKKPKAVKPK KVAKSPAKAKAVKPKGAKVKVTKPKT*206AAKPKKAAPKKK
Predicted Disorder Regions (1-218)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.Citrullination of a single arginine residue within the DNA-binding site of H1 results in its displacement from chromatin and global chromatin decondensation.
Bibliography Christophorou MA, Castelo-Branco G, Halley-Stott RP, Oliveira CS, Loos R, Radzisheuskaya A, Mowen KA, Bertone P, Silva JC, Zernicka-Goetz M, Nielsen ML, Gurdon JB, Kouzarides T. Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature. 2014 Mar 6;507(7490):104-8. doi: 10.1038/nature12942. Epub 2014 Jan 26. PMID: 24463520; PMCID: PMC4843970.