Primary Information |
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| BoMiProt ID | Bomi6262 |
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| Protein Name | Histamine H1 receptor |
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| Organism | Bos taurus |
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| Uniprot ID | P30546 |
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| Milk Fraction | Whey |
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| Aminoacid Length | 491 |
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| Molecular Weight | 55957 |
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| FASTA Sequence |
Download |
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| Gene Name | HRH1/H1R/HH1R |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | nerves, respiratory epithelium, endothelial cells, hepatic cells, vascular smooth muscle cells, dendritic cells, and lymphocytes |
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| Biochemical Properties | In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. |
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| Significance in milk | Mast Cell-Mediated Allergy and Inflammation |
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| PTMs | Phosphorylation on Ser and Thr.Glycosylation on Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P30546|HRH1_BOVIN Histamine H1 receptor OS=Bos taurus OX=9913 GN=HRH1 PE=2 SV=1
MTCPN*5SSCVFEDKMCQGN*18KTAPANDAQLTPLVVVLSTISLVTVGLNLLVLYAVRSERKLH
TVGNLYIVSLSVADLIVGVVVMPMNILYLLMSRWSLGRPLCLFWLSMDYVASTASIFSVF
ILCIDRYRSVQQPLKYLRYRT*141KT*143RASITILAAWFLSFLWIIPILGWRHFQPKTPEPREDK
CETDFYNVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINGS*231FPSFSDMKM
KPENLQVGAKKPGKESPWEVLKRKPKDTGGGPVLKPPSQEPKEVTSPGVFSQEKEEKDGE
LGKFYCFPLDTVQAQPEAEGSGRGYATINQSQNQLEMGEQGLSMPGAKEALEDQILGDSQ
SFSRTDSDTPAEPAPAKGKSRSES*384STGLEYIKFTWKRLRS*400HS*402RQYVSGLHMNRERKAAKQ
LGFIMAAFIICWIPYFIFFMVIAFCESCCNQHVHMFTIWLGYINSTLNPLIYPLCNENFK
KTFKKILHIRS |
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| Predicted Disorder Regions | 2 disordered segments; (4-20), (242-385) |
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| DisProt Annotation | |
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| TM Helix Prediction | 7 TMHs;(31-53),(65-87),( 102-124),( 145-163),(193-215),(421-443) & (458-476) |
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| Significance of PTMs | Phosphorylation in 2nd and 3rd cytoplasmic loops contribute to agonist-induced receptor downregulation. |
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