Search by BoMiProt ID - Bomi6236


Primary Information

BoMiProt ID Bomi6236
Protein Name Heterogeneous nuclear ribonucleoprotein A1 /Helix-destabilizing protein/Single-strand RNA-binding protein/Unwinding protein 1/hnRNP core protein A1
Organism Bos taurus
Uniprot IdP09867
Milk FractionWhey
Ref Sequence Id NP_001039376.1
Aminoacid Length 320
Molecular Weight 34196
Fasta Sequence https://www.uniprot.org/uniprot/P09867.fasta
Gene Name HNRNPA1/HNRPA1
Gene Id 505093
Protein Existence Status reviewed

Secondary Information

Protein Function associate with nascent RNA polymerase II transcripts to yield hnRNP particles, playing key roles in mRNA metabolism, DNA-related functions and microRNA biogenesis.key roles in neuronal functioning and its depletion, either due to debilitated cholinergic neurotransmission or under autoimmune reactions.HnRNP A1 modulates alternative splicing of APP, inhibiting the generation of toxic Aβ thus protecting from Alzheimer's disease.
Biochemical Properties it is a DNA biniding protein.N-terminal half of the protein is composed of two similar globular regions in tandem; the major part of each is an RNA-recognition motif (RRM). These two RRMs, referred to as RRM1 and RRM2, show high sequence similarity.RRMs are compact structures composed of a four β-strands sheet adjoined by two α-helices, in a structure of β1α1β2β3α2β4C-terminal half of hnRNP A1 is compositionally biased, being enriched by glycine residues. This half of the protein harbors an RNA-binding motif, present in some of the hnRNP protein variants, and a nuclear targeting sequence.
PTMs Phosphorylation on Serine by MKNK2,Acetylation, Isopeptide bond, Methylation,Ubl conjugation.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 3 predicted disordered segments; (2-14), (182-191), (305-320)
DisProt Annotation
TM Helix Prediction No TM helices
Significance of PTMs post-translational modifications alter both its nuclear pore shuttling properties and its RNA interactions and affect transcription, mRNA splicing and microRNA biogenesis
Linking IDs
Bibliography Bekenstein U, Soreq H. Heterogeneous nuclear ribonucleoprotein A1 in health and neurodegenerative disease: from structural insights to post-transcriptional regulatory roles. Mol Cell Neurosci. 2013 Sep;56:436-46. doi: 10.1016/j.mcn.2012.12.002. Epub 2012 Dec 14. PMID: 23247072.