Search by BoMiProt ID - Bomi6233


Primary Information

BoMiProt ID Bomi6233
Protein Name Heterochromatin protein 1-binding protein 3
Organism Bos taurus
Uniprot IDQ08DU9
Milk FractionWhey
Ref Sequence ID NP_001068904.1
Aminoacid Length 555
Molecular Weight 61477
FASTA Sequence Download
Gene Name HP1BP3
Gene ID 510194
Protein Existence Status Reviewed

Secondary Information

Presence in other biological fluids/tissue/cells  female gonad
Protein Function Hp1bp3 was identified as a candidate marker of intrinsic 5-FU resistance and may represent a potential biomarker for patient stratification or a target of clinical importance.
Biochemical Properties Tight binding of HP1BP3 protein to linker DNA at the entry/exit site of nucleosomal DNA involves a long N-terminal extension, globular core, and basic C-terminal tail 
PTMs Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|Q08DU9|HP1B3_BOVIN Heterochromatin protein 1-binding protein 3 OS=Bos taurus OX=9913 GN=HP1BP3 PE=2 SV=1 MATDTS*6QGELVHPKALPLIVGAQLIHADKLGEKVEDNTMPIRRAVNSTRET*51PPKSKLAEG VEEKPEPDVSSEESISTVEEQENET*85PPATSSETEQPKGQPENEEKEENKPSEETKKDEKD QSKEKEKKVKKTIPSWATLSAS*142QLARAQKQTPMAS*155S*156PRPKMDAILTEAIKACFQKSGASV VAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKSRKPPQK SRNRKNRS*248S*249AVDPEPQVKLEDILPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQL LKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCS TTALKKYVLENHPGTNSNYQMHLLKKTLQRCEKNGWMEQISGKGFSGTFQLCFPYYPSPG VLFPKKEPDDSKDEDEDEDEDDS*443S*444EEDS*448EDEEPPPKRRLQKKTPVKSPGKAAAMKQRGSK LAPKVPAAQRGKTRPLPKKAPPKAKSPAKKARPSPSVIKKPSGSSSKKPAASVRKEVKLP GKGKSTMKKSFKAKK
Predicted Disorder Regions 1-3, 29-181, 218-260, 313-334, 413-555
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments knockdown of Hp1bp3 in the hippocampus by 50%-75% is sufficient to induce cognitive deficits and transcriptional changes reminiscent of those observed in aging and Alzheimer's disease brains. 
Bibliography 1.Hadac JN, Miller DD, Grimes IC, Clipson L, Newton MA, Schelman WR, Halberg RB. Heterochromatin Protein 1 Binding Protein 3 Expression as a Candidate Marker of Intrinsic 5-Fluorouracil Resistance. Anticancer Res. 2016 Mar;36(3):845-52. PMID: 26976970; PMCID: PMC4876978. 2.Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K. The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA. J Biol Chem. 2010;285:6498–6507. 3.Neuner SM, Ding S, Kaczorowski CC. Knockdown of heterochromatin protein 1 binding protein 3 recapitulates phenotypic, cellular, and molecular features of aging. Aging Cell. 2019 Feb;18(1):e12886. doi: 10.1111/acel.12886. Epub 2018 Dec 13. PMID: 30549219; PMCID: PMC6351847.