Search by BoMiProt ID - Bomi6228


Primary Information

BoMiProt ID Bomi6228
Protein Name Hepatocyte nuclear factor 3-gamma/HNF-3-gamma/Forkhead box protein A3
Organism Bos taurus
Uniprot IdQ3Y598
Milk FractionWhey
Ref Sequence Id NP_001028291.1
Aminoacid Length 351
Molecular Weight 37138
Fasta Sequence https://www.uniprot.org/uniprot/Q3Y598.fasta
Gene Name FOXA3/HNF3G
Gene Id 503622
Protein Existence Status reviewed

Secondary Information

Protein Function Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes
Significance in milk Glucose homeostasis.also involved in negative energy balance which is an altered metabolic state, occurs in early postpartum dairy cattle when energy demands to support lactation exceed energy intake.
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions (27-33), (46-113), (215-230), (239-274), (300-306), (320-331)
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography 1.Fatima, A., Waters, S., O'Boyle, P., Seoighe, C., & Morris, D. G. (2014). Alterations in hepatic miRNA expression during negative energy balance in postpartum dairy cattle. BMC genomics, 15, 28. https://doi.org/10.1186/1471-2164-15-28 2.Hiemisch, H., Schütz, G., & Kaestner, K. H. (1997). Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis. The EMBO journal, 16(13), 3995–4006. https://doi.org/10.1093/emboj/16.13.3995