Search by BoMiProt ID - Bomi6227


Primary Information

BoMiProt ID Bomi6227
Protein Name Hepatocyte growth factor/Hepatopoietin-A/Scatter factor/SF
Organism Bos taurus
Uniprot IdQ76BS1
Milk FractionWhey
Ref Sequence Id NP_001026921.1
Aminoacid Length 730
Molecular Weight 83357
Fasta Sequence https://www.uniprot.org/uniprot/Q76BS1.fasta
Gene Name HGF
Gene Id 282879
Protein Existence Status reviewed

Secondary Information

Protein Function Potent mitogen for mature parenchymal hepatocyte cells.known to promote growth of hepatocytes.imp for synaptic plasticity.involved in breakdown of the extracellular matrix.Suppression of chronic inflammation.
Biochemical Properties a heparin-binding protein.contains disulfide bond linked light and heavy chains.Binds to Met receptor.HGF contains NK1 domain which is important for high affinity binding to Met and Met dimerization and A Beta chain domain which has low affinity for Met Receptor.
PTMs disulfide bond formation,Glycosylation.Proteolytic cleavage
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 1TMH; (7-29)
Significance of PTMs HGF is biosynthesized as a prepro-form of 728 amino acids, including a signal sequence and both α- and β-chains. After cleavage of a signal peptide of the first 31 amino acids, a single-chain HGF is further cleaved between Arg494 and Val495, and this processing is coupled to the conversion of biologically inactive pro-HGF to active HGF.
Linking IDs