Primary Information |
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| BoMiProt ID | Bomi6224 |
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| Protein Name | Heparanase |
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| Organism | Bos taurus |
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| Uniprot ID | Q9MYY0 |
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| Milk Fraction | Whey,MFGM |
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| Ref Sequence ID | NP_776507.1 |
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| Aminoacid Length | 545 |
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| Molecular Weight | 61077 |
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| FASTA Sequence |
Download |
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| Gene Name | HPSE |
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| Gene ID | 281230 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | HPSE regulates the classic and emerging hallmarks of cancer as well as regulating pro inflammatory immune cell migration and activation. |
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| Biochemical Properties | Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth factors and cytokines bound to heparan sulphate. This in turn promotes both physiological and pathological processes such as angiogenesis, immune cell migration, inflammation, wound healing and metastasis. |
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| Significance in milk | Granulosa-derived heparanase is a novel member of the luteinizing hormone-induced extracellular matrix-degrading enzymes contributing to follicular rupture and ovulation. |
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| PTMs | N-linked Glycosylation at Asn |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|Q9MYY0|HPSE_BOVIN Heparanase OS=Bos taurus OX=9913 GN=HPSE PE=2 SV=2
MLACRKPGLRPPLLLLLPLLGPLGPCSPGTPAAAAPADDAAELEFFTERPLHLVSPAFLS
FTIDANLATDPRFFTFLGSSKLRTLARGLAPAYLRFGGNKGDFLIFDPKKEPAFEERSYW
LSQSNQDICKSGSIPSDVEEKLRLEWPFQEQVLLREQYQKKFTN*164STYSRSSVDMLYTFAS
CSGLNLIFGVNALLRTTDMHWDSSNAQLLLDYCSSKNYN*219ISWELGNEPNSFQRKAGIFIN
GRQLGEDFIEFRKLLGKSAFKNAKLYGPDIGQPRRNTVKMLKSFLKAGGEVIDSVTWHHY
YVNGRIATKEDFLNPDILDTFISSVQKTLRIVEKIRPLKKVWLGETSSAFGGGAPFLSNT
FAAGFMWLDKLGLSARMGIEVVMRQVLFGAGNYHLVDGNFEPLPDYWLSLLFKKLVGNKV
LMASVKGPDRSKFRVYLHCTNTKHPRYKEGDLTLYALNLHN*461VTKHLELPHHLFNKQVDKY
LIKPSGTDGLLSKSVQLNGQILKMVDEQTLPALTEKPLHPGSSLGMPPFSYGFFVIRNAK
VAACI |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Additional Comments | However, recent discoveries which demonstrated that heparanase can also regulate vital anti-tumour mechanisms have cast doubt on the cancer hallmark approach. |
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| Bibliography | Jayatilleke KM, Hulett MD. Heparanase and the hallmarks of cancer. J Transl Med. 2020 Nov 30;18(1):453. doi: 10.1186/s12967-020-02624-1. PMID: 33256730; PMCID: PMC7706218. 2.Eyal Klipper, Ehud Tatz, Tatiana Kisliouk, Israel Vlodavsky, Uzi Moallem, Dieter Schams, Yaniv Lavon, David Wolfenson, Rina Meidan, Induction of Heparanase in Bovine Granulosa Cells by Luteinizing Hormone: Possible Role during the Ovulatory Process, Endocrinology, Volume 150, Issue 1, 1 January 2009, Pages 413–421, https://doi.org/10.1210/en.2008-0697 |
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