Search by BoMiProt ID - Bomi6180


Primary Information

BoMiProt ID Bomi6180
Protein Name H(+)/Cl(-) exchange transporter 7/Chloride channel 7 alpha subunit/Chloride channel protein 7/ClC-7
Organism Bos taurus
Uniprot IdQ4PKH3
Milk Fractionwhey
Ref Sequence Id NP_001020502.1
Aminoacid Length 809
Molecular Weight 88831
Fasta Sequence https://www.uniprot.org/uniprot/Q4PKH3.fasta
Gene Name CLCN7
Gene Id 513545
Protein Existence Status Reviewed

Secondary Information

Protein Function voltage-gated channel mediating the exchange of chloride ions against proton.acidification of the lysosome lumen and may be involved in maintaining lysosomal pH.
Biochemical Properties functions as antiporter.2 chloride(in) + H+(out) = 2 chloride(out) + H+(in). presence of conserved gating glutamate residues is imp for its function.
PTMs phosphorylation on ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions NA
DisProt Annotation
TM Helix Prediction 11TMHs; (130-152), (179-201), (231-249), (292-314), (327-349), (381-403), (416-438), (492-510), (517-539), (551-573), (580-602)
Additional Comments Loss of CLC-7 transporters leads to lysosomal storage diseases and osteopetrosis 
Bibliography Lin J, Wei J, Lv Y, Zhang X, Yi RF, Dai C, Zhang Q, Jia J, Zhang D, Huang Y. H(+)/Cl(‑) exchange transporter 7 promotes lysosomal acidification‑mediated autophagy in mouse cardiomyocytes. Mol Med Rep. 2021 Mar;23(3):222. doi: 10.3892/mmr.2021.11861. Epub 2021 Jan 26. PMID: 33495814; PMCID: PMC7845584.