Search by BoMiProt ID - Bomi6173


Primary Information

BoMiProt ID Bomi6173
Protein Name Guanine nucleotide-binding protein-like 3-like protein
Organism Bos taurus
Uniprot IdQ3T0J9
Milk FractionWhey
Ref Sequence Id NP_001029479.1
Aminoacid Length 575
Molecular Weight 64837
Fasta Sequence https://www.uniprot.org/uniprot/Q3T0J9.fasta
Gene Name GNL3L
Gene Id 507679
Protein Existence Status reviewed

Secondary Information

Protein Function GNL3L-LDOC1 interplay regulates cell proliferation through the modulation of NF-κB pathway during tumorigenesis.
Biochemical Properties A Novel Lysine-rich Domain and GTP Binding Motifs Regulate the Nucleolar Retention of Human Guanine Nucleotide Binding Protein, GNL3L.
PTMs Ubl conjugation
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
NA
Predicted Disorder Regions 1-31, 491-510, 571-575
DisProt Annotation
TM Helix Prediction No TM helices
Additional Comments  mutations within the G-domains alter the GTP binding ability of GNL3L and abrogate wild-type nucleolar retention even in the presence of functional NoLS
Bibliography 1.Rao MR, Kumari G, Balasundaram D, Sankaranarayanan R, Mahalingam S. A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L. J Mol Biol. 2006 Dec 8;364(4):637-54. doi: 10.1016/j.jmb.2006.09.007. Epub 2006 Sep 8. PMID: 17034816. 2.Thoompumkal IJ, Rehna K, Anbarasu K, Mahalingam S. Leucine Zipper Down-regulated in Cancer-1 (LDOC1) interacts with Guanine nucleotide binding protein-like 3-like (GNL3L) to modulate Nuclear Factor-kappa B (NF-κB) signaling during cell proliferation. Cell Cycle. 2016 Dec;15(23):3251-3267. doi: 10.1080/15384101.2016.1242534. Epub 2016 Oct 20. PMID: 27764577; PMCID: PMC5176145.