Primary Information |
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| BoMiProt ID | Bomi6154 |
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| Protein Name | GTPase Era, mitochondrial/ERA-like protein 1 |
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| Organism | Bos taurus |
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| Uniprot Id | A5PK43 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_001092492.1 |
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| Aminoacid Length | 437 |
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| Molecular Weight | 48567 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/A5PK43.fasta |
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| Gene Name | ERAL1 |
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| Gene Id | 523344 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Protein Function | Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly |
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| PTMs | Phosphorylation |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|A5PK43|ERAL1_BOVIN GTPase Era, mitochondrial OS=Bos taurus OX=9913 GN=ERAL1 PE=2 SV=1
MAASSWRGAVLLRTVSGLWQAGPDAAREWMTRLPSLLGFQQRCVSCVAGPAFSGPRLASA
SRPNGQNSALDCFLGLSQPDNSLPFRVPAVSVHRDEQDLLLVHRPDMPENPRVLRVVLLG
APNAGKSTLSNQLLGRKVFPVSKKVHTTRSQALGVITEKETQVILLDTPGLIS*173PAKQKRH
HLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQVLRCLTQFSQVPSILVMNKVDC
LKQKSVLLELTAALTEGVVNGKKLKTKQALRSRPDTHCPSPAAQGPNPQPVRDPQQMGWP
HFQEIFMLSALSQEDVKTLKQYLLAQARPGPWEFHSEVLTSQTPEEICANMIREKLLEYL
PEEVPYNVQQKTVVWDEGPSGELVIEQKLLVSKESHMKILIGPKGYLIAQIAQEVGRDLM
NIFLCEVQLRLSVKLLK |
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| Predicted Disorder Regions | NA |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | Dennerlein, S., Rozanska, A., Wydro, M., Chrzanowska-Lightowlers, Z. M., & Lightowlers, R. N. (2010). Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit. The Biochemical journal, 430(3), 551–558. https://doi.org/10.1042/BJ20100757 |
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