Primary Information |
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| BoMiProt ID | Bomi6074 |
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| Protein Name | Glycylpeptide N-tetradecanoyltransferase 1/Myristoyl-CoA:protein N-myristoyltransferase 1/Peptide N-myristoyltransferase 1 |
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| Organism | Bos taurus |
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| Uniprot ID | P31717 |
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| Milk Fraction | Exosomes |
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| Aminoacid Length | 497 |
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| Molecular Weight | 56919 |
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| FASTA Sequence |
Download |
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| Gene Name | NMT1 |
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| Protein Existence Status | Reviewed |
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Secondary Information |
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| Protein Function | N-myristoyltransferase-1 (NMT1) catalyzes protein posttranslational myristoylation and functions as an oncogene in various cancers and it may represent a novel clinical intervention in bladder cancer. |
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| PTMs | Phosphorylation at serine |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| >sp|P31717|NMT1_BOVIN Glycylpeptide N-tetradecanoyltransferase 1 OS=Bos taurus OX=9913 GN=NMT1 PE=1 SV=2
MGDESETAVKPPAPPLPQMMEGNGNGHEHCS*31DCENEEDNSYNRGGLS*47PANDTGAKKKKKK
QKKKKEKGSETDSAQDQPVKMNS*83LPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFW
DTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENY
VEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEK
KMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRS
LNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMEKKDIPVVHQLLSRYLKQF
HLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAY
SFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNNLQYYLY
NWKCPSMGAEKVGLVLQ |
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| Predicted Disorder Regions | 1-117, 128-148 |
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| DisProt Annotation | |
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| TM Helix Prediction | No TM helices |
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| Bibliography | 1.McIlhinney RA, McGlone K, Willis AC. Purification and partial sequencing of myristoyl-CoA:protein N-myristoyltransferase from bovine brain. Biochem J. 1993 Mar 1;290 ( Pt 2)(Pt 2):405-10. doi: 10.1042/bj2900405. PMID: 8452528; PMCID: PMC1132288. 2.Sun Y, Guan Z, Sheng Q, Duan W, Zhao H, Zhou J, Deng Q, Pei X. N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression. Cancer Lett. 2022 Mar 31;529:126-138. doi: 10.1016/j.canlet.2022.01.001. Epub 2022 Jan 6. PMID: 34999170. |
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