Search by BoMiProt ID - Bomi6


Primary Information

BoMiProt ID Bomi6
Protein Name Serum albumin
Organism Bos taurus
Uniprot IdP02769
Milk FractionWhey
Ref Sequence Id NP_851335.1
Amino Acid Lenth 607
Molecular Weight 69293
Fasta Sequence http://www.uniprot.org/uniprot/P02769.fasta
Gene Name ALB
Gene Id 280717
Protein Existence Status Reviewed: Experimental evidence at protein level

Secondry Information

Presence in other biological fluids/tissue/cells serum, milk, tear, urine
Endogenous/Bioactive peptides - Fragment - Sequence - Effect Albutensin A - 208–216 - ALKAWSVAR - Ileum contraction, ACE inhibition Ref
Serophin - 399–404 - YGFQDA - Opioid Ref
Protein Function Regulate colloidal osmotic pressure of blood; maintains blood pH; transports metal ions, insoluble small molecules and nutrients (including long chain fatty acids) to various organs; key role in drug thermodynamics and pharmacodynamics; degrades into amino acids and provides nutrition to cells;major source of energy for tumor growth; used as a fusion protein; controls concentration of Ca2+ and Mg2+ in mammals
Biochemical Properties Binds to compounds in a reversible manner; form complexes with aromatic ligands; increase in temperature shifts α - helix to random coil; highly soluble in pH 7 and 4; reversibility of denaturation is high at low concentration if heated upto 100°C; abundant disulfide bridges; single free thiol; long circulatory half-life
Significance in milk Reflects the progression in lactation stage; elevated in pathologically damaged epithelium of bovine teats; activation of autoimmunity through molecular mimmicry
PDB ID 2l7u, 3v03, 4f5s, 4jk4, 4or0,
Additional Comments In solution, the different isomeric forms of serum albumin exist depending on pH value; synthesized in the liver without prosthetic groups; one of the few plasma protein groups lacking carbohydrates; owing to good water-solubility,ready availability,biodegrad- ability, lack of toxicity,minimal immunogenicity,and its preferential accumulation in tumor and inflamed tissues make it an ideal carrier for drug delivery
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