Search by BoMiProt ID - Bomi5973


Primary Information

BoMiProt ID Bomi5973
Protein Name General transcription factor IIE subunit 1/Transcription initiation factor IIE subunit alpha/TFIIE-alpha
Organism Bos taurus
Uniprot IDA6QLI8
Milk FractionWhey
Ref Sequence ID NP_001096764.1
Aminoacid Length 438
Molecular Weight 49211
FASTA Sequence Download
Gene Name GTF2E1
Gene ID 540525
Protein Existence Status reviewed

Secondary Information

Protein Function TFIIE helps in the recruitment of TFII regulates TFIIH kinase activity that phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II.
Biochemical Properties TFIIE binds Gal11 protein, a component of the Mediator, and that TFIIE-Gal11 interaction en-hances TFIIH-catalyzed phosphorylation of the CTD.
PTMs Acetylation Ala and Lys and phosphorylation on Ser
Site(s) of PTM(s)

N-glycosylation, O-glycosylation,
Phosphorylation
>sp|A6QLI8|T2EA_BOVIN General transcription factor IIE subunit 1 OS=Bos taurus OX=9913 GN=GTF2E1 PE=2 SV=1 MADPDVLTEVPAALKRLAKYVIRGFYGIEHALALDILIRNPCVKEEDMLELLKFDRKQLR SVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDHMRRRIETDERD STNRASFKCPVCSSTFTDLEANQLFDPMTGTFRCTFCQTEVEEDESAMPKKDARTLLARF NEQIEPIYALLRETEDVNLAYEILEPEPTEIPALKQSKDRAATAAGAAGLAGGHHREAWT TKGPSYEDLYTQNVVINMDDQEDLHRAS*268LEGKSAKERPIWLRESTVQGAYNSEEMKEGGI DIDSFQEHEEGHAGPDDNEEVMRALLIHEKKTPSAPAGSVGAAAPVTAANGSDSESETSE SDDDSPPRVATVAAHHGEEDEEDDEFEEVADDPVVMVAGRPFSYSEVSQKPELVAQMTPE EKEAYIAMGQRMFEDLFE
Predicted Disorder Regions 215-251, 261-410, 419-423,
DisProt Annotation
TM Helix Prediction No TM helices
Bibliography Sakurai H, Fukasawa T. Activator-specific requirement for the general transcription factor IIE in yeast. Biochem Biophys Res Commun. 1999 Aug 11;261(3):734-9. doi: 10.1006/bbrc.1999.1113. PMID: 10441494.