Primary Information |
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| BoMiProt ID | Bomi5946 |
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| Protein Name | Gastrin-releasing peptide |
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| Organism | Bos taurus |
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| Uniprot Id | Q863C3 |
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| Milk Fraction | Whey |
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| Ref Sequence Id | NP_001094709.1 |
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| Aminoacid Length | 134 |
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| Molecular Weight | 14934 |
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| Fasta Sequence | https://www.uniprot.org/uniprot/Q863C3.fasta |
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| Gene Name | GRP |
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| Gene Id | 615323 |
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| Protein Existence Status | reviewed |
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Secondary Information |
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| Presence in other biological fluids/tissue/cells | is present in a variety of different mammalian tissues, in particular the brain, the gastrointestinal (GI) tract, and the lung. |
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| Protein Function | Stimulates the release of gastrin and other gastrointestinal hormones.GRP acts by binding to the GRP receptor (GRPR, also called BB2), a member of the G-protein coupled receptor (GPCR) superfamily. GRP produced by neurons in the central nervous system (CNS) plays a role in synaptic transmission by activating GRPRs located on postsynaptic membranes, influencing several aspects of brain function. |
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| Biochemical Properties | is a 27-amino acid mammalian neuropeptide |
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| Significance in milk | Immunoreactive and increase smooth muscle tone and rhythmic contractions |
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| PTMs | Amidation, Cleavage on pair of basic residues |
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Site(s) of PTM(s)
N-glycosylation,
O-glycosylation,
Phosphorylation
| NA |
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| Predicted Disorder Regions | 4 disordered segments;(1-5), (26-41), (45-79), (83-134) |
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| DisProt Annotation | |
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| TM Helix Prediction | 1TMH; (7-29) |
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| Bibliography | 1.Foy WL, Allen JM, McKillop JM, Goldsmith JP, Johnston CF, Buchanan KD. Substance P and gastrin releasing peptide in bovine mesenteric lymphatic vessels: chemical characterization and action. Peptides. 1989 May-Jun;10(3):533-7. doi: 10.1016/0196-9781(89)90138-1. PMID: 2476787. 2.Roesler R, Kent P, Luft T, Schwartsmann G, Merali Z. Gastrin-releasing peptide receptor signaling in the integration of stress and memory. Neurobiol Learn Mem. 2014 Jul;112:44-52. doi: 10.1016/j.nlm.2013.08.013. Epub 2013 Aug 31. PMID: 24001571. |
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